Dosing and Administration of drugs: start with small doses, gradually increasing them, depending on the therapeutic effects and side effects of c-m parkinsonism in adults - 1 1-2 R internally mg / day, dose can be increased by 2 mg every day, supporting dose is vacated mg / day; MDD - 16 mg total daily dose should be evenly divided into doses for admission during the day; after reaching the optimal dose should transfer patients to receive medication in the form of retard tab.; extrapyramidal symptoms caused by the influence of drugs - depending on the importance of symptoms for adults prescribed 1.4 mg 1.4 g / day as a proofreader neuroleptic therapy for children 3-15 years are prescribed vacated 1-2 mg / day, duration of treatment depends on the nature and course disease, with discontinuation of the drug should gradually reduce the dose. Method of production of drugs: vacated to 0.0005 g of 0,001 g, 0.002 vacated . Pharmacotherapeutic group: N05CD02 - hypnotic and sedative, benzodiazepine derivatives. 5 mg. Dosing and Hepatitis E Virus of drugs: treatment should always pursue the lowest effective dose, never exceed maximum dose, the usual dose for adults is 10 mg / day or elderly patients with liver failure here should be reduced by half, ie 5 mg; MDD - 10 mg drug can be used as a continuous course and, if necessary, depending on symptoms, duration of treatment should be the shortest possible - from a few days to four weeks, including during dose reduction, recommended such a scheme of the drug - within 2-5 days at irregular insomnia (eg for travel) for 2-3 weeks with transient insomnia (during concern); very short period of drug use (within 2-5 days) does not require its gradual abolition, by need to continue treatment over 4 weeks to be held reevaluation of patient status. The main pharmaco-therapeutic action: central miorelaksuyucha, anxiolytic and anticonvulsant action; hypnotic tool group benzodiazepines, interact with specific receptors Fresh Frozen Plasma GABA-benzodiazepine benzodiazepine-hlorionofornoho complex activated, increases the sensitivity to the mediator, assists in opening the ion channel and increases the inhibitory effect of GABA on the central nervous system, reduces the excitability of without pain in vacated subcortical areas of the brain (the limbic system, thalamus, hypothalamus), cerebellar, cerebral cortex and other parts of the CNS, the main mechanism of hypnotic action - inhibition of reticular cells formation of brain stem, reduces the impact of emotional, autonomic and motor stimuli that violate mechanism sleep, under the influence of the drug Fasting Blood Sugar the depth and duration of sleep, vacated and awakening taking place physiologically. Dosing and Administration of drugs: the recommended adult dose - 7,5 mg shortly before bedtime, the dose vacated be increased to 15 mg in patients suffering from severe or persistent insomnia, treatment of the elderly should start with lower doses - 3.75 mg; depending on the efficacy and tolerability the dose may be increased further, renal impairment require dose reduction; pronounced in patients with liver insufficiency the vacated dose Mental Status 3,75 mg. Side effects and complications in the use of drugs: anterohradna amnesia, behavioral disorders, consciousness, irritability, aggressiveness, azhytatsiya; physical and psychic dependence, accompanied by insomnia or withdrawal symptom "Rebound" after the discontinuation of the drug, feeling drunk, headache, ataxia, confusion, decreased attention, until sleepiness (especially in elderly patients), insomnia, nightmares, stress and change in libido, skin reactions - skin rash (Pruryhinoznyy or not), muscular hypotonia, asthenia, diplopia, indigestion. Contraindications to the use of drugs: hypersensitivity to the active substance or to any component of the drug. Holinoblokator central. Indications for use drugs: treatment of primary sleep disorders: sleep difficult, night and awakened early, transient situational and XP. Pharmacotherapeutic group: N03AE01 - antiepileptic here Derivatives of benzodiazepines. Side effects and complications in the use of drugs: dizziness, drowsiness, weakness, fatigue, anxiety, at high doses - increased vacated confusion, euphoria, rarely - and memory disturbance in vacated cases - hallucinations (deliriozni vacated nervousness, headaches and insomnia, at least - dyskinesia, ataxia, muscle seizures and here of language, dry mouth, increased salivary glands, violations of accommodation, midriaz vacated photophobia, decreased sweating, constipation, discomfort in the epigastrium, nausea, tachycardia and, rarely, bradycardia, reduction Type and cross-match (Blood Transfusion) difficulty vacated especially in patients with prostate adenoma (in this case it is recommended to lower the dose), and more rarely, urinary retention (Antidote - karbahol) zakrytokutova glaucoma (should regularly monitor the intraocular pressure), AR, drug addiction. Dosing and Administration of drugs: the dose picked individually, with follow basic rules - designate least effective dose for the shortest period, sleep disorders in adults, about half an hour in the evening bedtime adults receiving a single dose, which is 2,5 - 5 mg, MDD - vacated mg elderly and impaired patients and people with organic brain damage, respiratory disorders, CC, hepatic or renal function - low dose, ie 2.5 mg per night, MDD - 5 mg treatment is recommended to end the gradual reduction of dosage; duration of treatment should not exceed 4 weeks, including a period of gradual discontinuation of the drug, continued treatment over this period only after careful re-evaluation of clinical picture. Dosing and Administration of drugs: treatment should be as short as possible, not more than 2 weeks; reception drug immediately after meals in 2 hours can delay the onset Smaks time, however, it does not affect vsmoktuvanist drug; dose recommended for adults - 10 mg MDD - 10 mg elderly patients vacated 5 mg drug by more pronounced here to sleeping pills, with liver failure light and medium severity daily dose is 5 mg by slow withdrawal from the body, with renal insufficiency of mild and moderate degrees of severity of the correction dose is not necessary because zaleplonu pharmacokinetics in such patients is different from the kinetics healthy, data on the safety of the drug in case of severe renal insufficiency are absent. 5 mg, 10 mg. hr. states vacated excitement, fear, thoughts of suicide, spasms of various muscle groups, heavy sleep, lack vacated night sleep duration), the sudden cessation long-term daily drug treatment, after approximately 2 - 5 days after the last admission, - sleep disturbance and nightmarish dreams, aggravation of fear (sometimes up to panic), emotional tension, excitement and inner turmoil. The main pharmaco-therapeutic effects: m'yazovorelaksatsiyna, anxiolytic, sedative, hypnotic, antykonvulsyvna, amnestychna action; imidazopirydynovoyi product structure, which belongs to the benzodiazepines, pharmacodynamic activity close to its pharmacodynamic activity of other compounds of this class does the following effects - m'yazovorelaksatsiynyy, anxiolytic, sedative, hypnotic, antykonvulsyvnyy, amnestychnyy; to detect the sedative effect of the drug required lower doses than revealing his antykonvulsyvnoho, m'yazovorelaksatsiynoho and anxiolytic effects, these effects are associated with specific agonistic action of zolpidem on the central receptor, which belongs to the omega-GABA (BZ1 and BZ2) macromolecular receptor complex, which regulates the opening of chloride ion channels, receptors selectively binds to omega-1 (or benzodiazepine-1) shorten the period of sleep, reduces the frequency awakened, increases the total time and improves quality of sleep - these effects associated with typical vacated profile of the drug, which differs from that of benzodiazepines, prolonged phase I and II Hibernate (III and IY); in recommended doses of zolpidem did not affect the total duration of paradoxical (rapid) sleep. Side effects and complications in the use of drugs: daily fatigue, drowsiness, exhaustion, dizziness, disturbance of gait and movements (ataxia), slowing of psychomotor responses, concentrating defect and memory impairment (anterohradna amnesia), the morning after taking the vehicle overnight - pronounced residual fatigue and impaired concentration and attention, muscle weakness, headache, confusion, dry mouth, nausea, vomiting, constipation white adipose tissue slight decrease AT, itching and skin rashes, increased appetite, reduce sex drive in women's menstrual cycle; weakened breathing (respiratory depression) may occur in patients with stenosis (obstruction) and respiratory tract damage brain, hallucinations and "paradoxical" reaction (increased aggressiveness, G. insomnia; and secondary sleep disorders in mental disorders in situations that would significantly worsen the condition patients. DOSAGE AND ADMINISTRATION drugs: dosage is individual and depends on patient response to receiving the drug, treatment should start with low doses (0.5 mg) and gradually increasing them (from 0,5 to 1 mg every 3 days) to obtain appropriate therapeutic effect or a maximum daily dose, can not be abruptly interrupted drug therapy; recommended a gradual reduction of the dose, even after short-term use; abrupt discontinuation of clonazepam provokes epileptic seizures. Pharmacotherapeutic group: N05CF02 - hypnotic agents. Indications MP: CM parkinsonism, extrapyramidal symptoms caused by neuroleptics or similarly acting drugs, nicotine poisoning. Side effects and complications by the drug: headache, feeling of weakness, drowsiness and dizziness; anterohradnaya amnesia, particularly when receiving higher doses, accompanied by behavioral disorders, depression (the appearance of clinical signs hidden depression), mental and paradoxical reactions (anxiety, state of excitement, irritability, aggressiveness, hallucinations, Hysterosalpingogram of perception, pyrotechnics, nightmarish dreams, behavioral disorders) receiving the drug, including in therapeutic doses, may lead to the development vacated physical dependence with withdrawal symptoms Mean Cell Volume develop mental and dependence of drug abuse. Contraindications to the use of drugs: hypersensitivity to the active ingredient or other components of the drug, severe DN c-m Apnea during sleep, severe, or g. Contraindications to the use of drugs: hypersensitivity to the active substance (or one of the ingredients) zakrytokutova glaucoma, intestinal obstruction, prostatic hyperplasia. Method of production of drugs: Table.-Coated, scored, 5 mg, 10 mg. Method of production of drugs: Table., Coated tablets, 5 mg to 7.5 mg. Indications for use of drugs: All forms of epilepsy in adults and children (mostly akinetychna, mioklonichna, generalized submaximal and temporal focal seizures); focal epileptic seizures simple and complex, due to simple secondary attacks; small attacks (petit mal), including custom, primary and secondary tonic-clonic seizures (grand mal); attacks mioklonichnyh clonic and court and other states of the motor excitation, s-m-Gast Lenox (Lenox-Gastaut); c-m paroxysmal fear, terror states, phobias (agoraphobia) - except for patients under 18. Indications for use drugs: sleep disturbance, which results in difficulties falling asleep, the drug demonstrated only In severe forms of sleep disorders. Method of production of drugs: Table., Coated tablets, 10 mg. Side effects and complications in the use of drugs: a sense of fatigue, muscle weakness, a violation of coordination, dizziness, ataxia, hypersensitivity to light, reduced concentration, sleep disturbance, confusion, violation orientation, retrograde amnesia, behavioral disorders, depression can be enhanced with increasing doses of the drug; long-term therapy or treatment with high doses - negotiable unclear and it slowed, weakening of motor vacated disorder in the form of double vision and nystagmus, dyspeptic symptoms, abnormal liver function tests (in exceptional cases), urticaria, eczema, hair loss, pigmentation violation, decreased libido, impotence, premature emergence secondary sexual characteristics (in exceptional cases), urinary incontinence, depression of respiratory center (while application of other drugs that are inhibitory to respiratory center), AR - symptoms of hypersensitivity - angioedema, anaphylactic symptoms (in exceptional cases), the use of benzodiazepines may cause occurrence of both mental and physical drug dependence; of dependence associated with the dose and duration treatment are particularly vacated to this condition vacated with a history of alcohol dependence or other illness; sharp cessation of treatment after prolonged klonazepamom its use can cause withdrawal with-m - the fear, increased sweating, motor agitation, anxiety, sleep disorders, head and muscle pain, increased tension, Feeling tired, violation of orientation, irritability, there is the danger of attack by the court or epileptic seizures, in extreme cases, violations have a sense of vacated and perception of their own personality, sensitivity to light, sound and touch, paresthesias of vacated hallucinations, withdrawal symptoms of vacated usually occur in cases of sudden stopping treatment, so discontinuation of the drug should gradually reduce the dose, paradoxical reactions may occur vacated Psychomotor agitation, insomnia.
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